THE EFFECTIVENESS OF ETHANOL EXTRACT OF JAMBLANG LEAVES (Syzygium cumini L.) IN INCREASING HDL LEVELS IN WISTAR RATS MODELS OF METABOLIC SYNDROME

One of the characteristics metabolic syndrome (MetS) is low high-density lipoprotein (HDL) levels. Jamblang leaves (Syzygium cumini L.) contain various phytochemicals, which have antihyperglycemic, antihyperlipidemic, and antioxidant properties. This study aims to demonstrate effectiveness ethanol extract jamblang in increasing HDL levels Wistar rats model MetS. A pretest-posttest with a control group design was conducted using 30 male rats, divided into five groups randomly, six for each group. Here, KN means normal group, K- negative P1, P2, P3: treatment that were administered 100 mg/kg/day, 150 200 mg/kg/day 28 days, respectively. The rat MetS developed by administering high-fat fructose diet streptozotocin-nicotinamide. data analyzed paired t-test one-way ANOVA (α=0.05). found administration P2 P3 increased significantly, but not P1 However, significantly higher compared Moreover, dose followed levels, although highest did reach level as